Agilent G6410B Triple Quadrupole LC/MS System

The Agilent G6410B Triple Quadrupole LC/MS System is a liquid chromatograph triple quadrupole mass spectrometer that performs MS/MS using three sets of parallel rods. The first quadrupole separates ions into precursor ions that are fragmented in the hexapole into product ions, which are separated by the second quadrupole. The fragments are then scanned through the third quadrupole resulting in a product-ion scan MS/MS, allowing the user to identify a compound's fingerprint. Within the Agilent G6410B Triple Quadrupole LC/MS System is the use of a glass, dielectric "cold" capillary that enhances desolvation and improves the focusing of high mass ions while minimizing chemical noise, as well as improving general ion focusing.

The Agilent G6410B Triple Quadruple LC/MS System features a mass range of 15 to 1,650 m/z, mass accuracy of < 0.1 u over 24 hours, and three different peak width settings (FWHM). This system also features an MS/MS sensitivity with a signal-to-noise ratio of > 20:1 at 5 x RMS, measured by injecting 0.5 pg of reserpine onto the column. The 6410 LC/MS achieves sensitivity and resolution specifications after autotune without manual user intervention. The G6410B can also be paired with Agilent's 1260 and 1290 Series LC modules, to deliver sensitive, reproducible analyses of target compounds in complex matrices.

The Agilent G6410B Triple Quadrupole LC/MS System can be controlled from the Agilent MassHunter Workstation Software, which allows for programs to run in data acquisition, qualitative analysis, and quantitative analysis for an all-in-one software bundle.

This Agilent system is in excellent condition and will be fully tested to perform at factory specifications before being shipped.

Agilent G6410B Triple Quadrupole LC/MS System Specifications

HPLC System Inspection and Recertification Checklist

• Verify uniformity of main and residential firmware across all components, updating as necessary to ensure compatibility
• Confirm successful communication between software and the HPLC system, validating data transfer integrity
• Check the degasser’s internal vacuum to confirm it reaches the specified vacuum level for optimal performance
• Replace inlet, outlet, purge valve, and pump seals in the system pump to maintain reliable operation
• Ensure system pump passes pressure and leak tests, confirming secure and efficient performance
• Replace all capillary tubing with new OEM stainless steel tubing for durability and precision
• Remove autosampler transport assembly, replace X and Y bearings, and thoroughly clean carrier rails to remove debris and contaminants
• Replace metering valve seal, autosampler needle, and needle seat for consistent sampling accuracy
• Test column compartment switching valve functionality and replace its seal if necessary
• Confirm column compartment passes thermostat test to maintain precise temperature control
• Remove and clean internal detector optics for clear and accurate signal detection
• Replace UV and Vis detector lamps to ensure optimal light source stability and performance
• Verify flow cell absorbance meets manufacturer’s specifications for accurate measurement
• Confirm system response to isocratic test sample, ensuring stable and reproducible results

Technician Inspection and Recertification Checklist: HPLC Systems

The Following Checklist Is to Be Performed on All Incoming and Outgoing Equipment

Task	Completed?	Remarks?
Verify firmware uniformity and update as necessary	Completed
Confirm software communication with HPLC system	Completed
Check degasser vacuum level for optimal performance	Completed
Replace inlet, outlet, purge valve, and pump seals	Completed
Ensure pump passes pressure and leak tests	Completed
Replace all capillary tubing with OEM stainless steel tubing	Completed
Remove autosampler transport assembly, replace bearings, and clean rails	Completed
Replace metering valve seal, autosampler needle, and needle seat	Completed
Test column compartment switching valve and replace seal if needed	Completed
Confirm thermostat test in column compartment	Completed
Clean internal detector optics	Completed
Replace UV and Vis detector lamps	Completed
Verify flow cell absorbance meets manufacturer’s specifications	Completed
Confirm system response to isocratic test sample	Completed

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