Agilent 6545A Q-TOF Mass Spectrometer

The Agilent 6545A Q-TOF Mass Spectrometer represents a significant advancement in mid-range quadrupole time-of-flight mass spectrometry, offering an unparalleled combination of resolving power and sensitivity, which is estimated to be up to five times greater than previous models. This instrument is expertly designed for diverse applications including pharmaceutical research, food safety, environmental testing, metabolomics, lipidomics, and other small molecule analyses. Featuring a newly developed fast autotune technology, the 6545A enhances sensitivity specifically for small molecules, improving detection limits and maintaining the integrity of fragile compounds. This innovative autotune also streamlines the optimization process, making it faster and more efficient, like an autofocus system in cameras but for mass spectrometry.

The system's robust ion optics are engineered to provide greater durability and consistency in results, extending the intervals between required maintenance. The introduction of new ion beam shaping optics further stabilizes the ion flow, enhancing analytical consistency and prolonging instrument uptime. Highly sophisticated new-generation electronics and power supplies increase the mass resolution performance and enhance mass accuracy to an impressive 0.8 ppm. These features ensure high precision in mass determination, crucial for complex sample analyses.

Agilent has also integrated cutting-edge enhancements in the MassHunter software suite with this system. These advancements include powerful data-mining capabilities that allow users to rapidly and accurately process and interpret analytical data, not just identifying peaks and data points, but also providing comprehensive answers based on the chemical data. The 6545A Q-TOF supports an extensive dynamic range of up to five decades, accommodating a wide variety of sample concentrations within a single analysis. It covers a broad mass range from m/z 50 to 10,000, allowing for flexible and extensive molecular weight analysis. The system's spectral acquisition rate is notably high, capturing 50 spectra per second in MS mode and 30 MS/MS spectra per second, which facilitates high-throughput screening and detailed product ion analysis in MS/MS mode.

Transitioning between positive and negative ion modes is seamless and swift, with a cycle completion time of just 1.5 seconds. This feature is particularly valuable in labs performing comprehensive compound analyses, as it minimizes downtime and maximizes productivity. Overall, the Agilent 6545A Q-TOF is designed to boost laboratory efficiency and analytical confidence, providing robust, high-productivity, and high-sensitivity performance across a variety of demanding applications. It sets a new standard for Q-TOF instruments, making it an essential tool for scientists seeking to push the boundaries of what is possible in their research.

This Agilent MS system was recertified and calibrated by a factory trained engineer and is ready to ship on demand. This system comes with everything needed for easy installation and setup. All of our equipment is fully tested to perform at factory specifications before being shipped.

Agilent 6545A Q-TOF Mass Spectrometer Specifications

Sensitivity, MS Mode, Electrospray On-Column, 400 uL/min Flow Rate	500:1 RMS (1 pg LC/MS injection of reserpine. Signal-to-noise for the reserpine (M+H)+ at m/z 609.2807 while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode)
Sensitivity, MS/MS Mode, Electrospray On-Column, 400 uL/min Flow Rate	1,500:1 RMS (1 pg LC/MS injection of reserpine. Signal-to-noise for most intense product ions (174, 195, 397, and 448 m/z) while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode)
Mass Resolving Power	45,000 FWHM at m/z 2,722 (measured after automatic tuning procedure)
Mass Accuracy - MS Mode, Electrospray On-Column, 400 uL/min	Less than 0.8 ppm RMS as measured from 10 repeat injections (measured at the (M+H)+ ion of reserpine (m/z 609.2807) using an internal mass reference)
Mass Accuracy - MS/MS Mode, Electrospray On-Column, 400 uL/min	Less than 2 ppm RMS on m/z 397 as measured from 10 repeat injections (product ion m/z 397 for reserpine)
Dynamic Range	Up to 5 decades (intrascan dynamic range on co-eluting components)
Mass Range	m/z 100 to 10,000 for extended mass range m/z 50 to 1,700 or 50 to 3,200 for both high resolution and extended dynamic range modes Quadrupole up to m/z 4,000
Spectral Acquisition Rate, MS Mode	50 spectra/second (m/z 50 to 1,700 in MS mode while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode)
Spectral Acquisition Rate, MS/MS Mode	30 MS/MS spectra/second (m/z 50 to 1,700 in MS/MS mode while maintaining a resolution of 40,000 at m/z 2,722 in 4 GHZ mode)
Positive to Negative Switching	1.5 seconds (complete cycle switching from positive to negative and positive modes allow for stabilization time)
Dimensions (H x D x W)	76 x 30 x 48 in. (193 x 76.2 x 121.9 cm)
Weight	375 lb. (170 kg)
Electrical Requirements	200-240VAC, 50/60Hz

Computer Specifications
Model	Dell Optiplex 7010 Desktop PC
Processor	Intel Core i5-6500 Processor 3.2GHz
RAM	16GB
Hard Drive	250GB Internal SSD
Operating System	Windows 10 Professional, 64bit

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